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Selected Publication
Solaimuthu B, Khatib A, Tanna M, Karmi A, Hayashi A, Abu Rmailah A, Lichtenstein M, Takoe S, Jolly MK, Shaul YD. (2024) The exostosin glycosyltransferase 1 (EXT1)/STAT3 axis is a driver of breast cancer aggressiveness. Proc Natl Acad Sci USA. 2024
Hayashi A, Ruppo S, Heilbrun EE, Mazzoni C, Adar S, Yassour M, Rmaileh AA, Shaul YD. GENI: A web server to identify gene set enrichments in tumor samples. Comput Struct Biotechnol J. 2023 Oct 31;21:5531-5537. doi: 10.1016/j.csbj.2023.10.053. PMID: 38034403; PMCID: PMC10681878.
Abu Rmaileh A, Solaimuthu B, Khatib A, Lavi S, Tanna M, Hayashi A, Ben Yosef M, Lichtenstein M, Pillar N, Shaul YD. DPYSL2 interacts with JAK1 to mediate breast cancer cell migration. J Cell Biol. 2022 Jul 4;221(7):e202106078. doi: 10.1083/jcb.202106078. Epub 2022 May 16. PMID: 35575798; PMCID: PMC9115587.
Solaimuthu, B., Hayashi, A., Khatib, A., Shaul, Y. D. Monitoring Breast Cancer Growth and Metastatic Colony Formation in Mice using Bioluminescence. <em>J. Vis. Exp.</em> (177), e63060, doi:10.3791/63060 (2021).
Khatib A, Solaimuthu B, Ben Yosef M, Abu Rmaileh A, Tanna M, Oren G, Schlesinger Frisch M, Axelrod JH, Lichtenstein M, Shaul YD. The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21420-21431.
Rmaileh AA, Solaimuthu B, Tanna M, Khatib A, Yosef MB, Hayashi A, Lichtenstein M, Shaul YD. Large-Scale Differential Gene Expression Transcriptomic Analysis Identifies a Metabolic Signature Shared by All Cancer Cells. Biomolecules. 2020 Apr 30;10(5):701. doi: 10.3390/biom10050701. PMID: 32365991; PMCID: PMC7277211.
Neumann-Raizel H, Shilo A, Lev S, Mogilevsky M, Katz B, Shneor D, Shaul YD, Leffler A, Gabizon A, Karni R, Honigman A, Binshtok AM. 2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels. Front Pharmacol. 2019 Oct 15;10:1198. doi: 10.3389/fphar.2019.01198.
Luu M, Pautz S, Kohl V, Singh R, Romero R, Lucas S, Hofmann J, Raifer H, Vachharajani N, Carrascosa LC, Lamp B, Nist A, Stiewe T, Shaul Y, Adhikary T, Zaiss MM, Lauth M, Steinhoff U, Visekruna A. The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes. Nat Commun. 2019 Feb 15;10(1):760.
Aebersold DM, Shaul YD, Yung Y, Yarom N, Yao Z, Hanoch T, Seger R. Correction for Aebersold et al., "Extracellular Signal-Regulated Kinase 1c (ERK1c), a Novel 42-Kilodalton ERK, Demonstrates Unique Modes of Regulation, Localization, and Function". Mol Cell Biol. 2017 Aug 28;37(18):e00322-17. doi: 10.1128/MCB.00322-17. Erratum for: Mol Cell Biol. 2004 Nov;24(22):10000-15. PMID: 28847972; PMCID: PMC5574047.
Gershkovitz M, Fainsod-Levi T, Khawaled S, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Fridlender ZG, Granot Z. Microenvironmental Cues Determine Tumor Cell Susceptibility to Neutrophil Cytotoxicity. Cancer Res. 2018 Sep 1;78(17):5050-5059. doi: 10.1158/0008-5472.CAN-18-0540. Epub 2018 Jul 2. PMID: 29967257.
Gershkovitz M, Caspi Y, Fainsod-Levi T, Katz B, Michaeli J, Khawaled S, Lev S, Polyansky L, Shaul ME, Sionov RV, Cohen-Daniel L, Aqeilan RI, Shaul YD, Mori Y, Karni R, Fridlender ZG, Binshtok AM, Granot Z. TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells. Cancer Res. 2018 May 15;78(10):2680-2690.
Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jul 19;12(8):656.
Shaul YD, Yuan B, Thiru P, Nutter-Upham A, McCallum S, Lanzkron C, Bell GW, Sabatini DM. MERAV: a tool for comparing gene expression across human tissues and cell types. Nucleic Acids Res. 2016 Jan 4;44(D1):D560-6. doi: 10.1093/nar/gkv1337. Epub 2015 Nov 30. PMID: 26626150; PMCID: PMC4702927.
Patterson HC, Gerbeth C, Thiru P, Vögtle NF, Knoll M, Shahsafaei A, Samocha KE, Huang CX, Harden MM, Song R, Chen C, Kao J, Shi J, Salmon W, Shaul YD, Stokes MP, Silva JC, Bell GW, MacArthur DG, Ruland J, Meisinger C, Lodish HF. A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5679-88.
Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032. PMID: 25171410; PMCID: PMC4250222.
Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y. Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27. PMID: 24469832; PMCID: PMC3926043.
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 2011 Aug 18;476(7360):346-50.
Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, Ali SM, Sengupta S, Shaul YD, Lamprecht MR, Madden KL, Papallo AR, Jones TR, Sabatini DM, Carpenter AE. Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. Genome Res. 2011 Mar;21(3):433-46.
Shaul YD, Gibor G, Plotnikov A, Seger R. Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade. Genes Dev. 2009 Aug 1;23(15):1779-90. doi: 10.1101/gad.523909. PMID: 19651986; PMCID: PMC2720265.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. PMID: 18497260; PMCID: PMC2475333.
Shaul YD, Seger R. The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta. 2007 Aug;1773(8):1213-26. doi: 10.1016/j.bbamcr.2006.10.005. Epub 2006 Oct 19. PMID: 17112607.
Shaul YD, Seger R. ERK1c regulates Golgi fragmentation during mitosis. J Cell Biol. 2006 Mar 13;172(6):885-97. doi: 10.1083/jcb.200509063. PMID: 16533948; PMCID: PMC2063732.
Shaul Y, Seger R. The detection of MAPK signaling. Curr Protoc Cell Biol. 2005 Oct;Chapter 14:Unit 14.3. doi: 10.1002/0471143030.cb1403s28. PMID: 18228462.
Aebersold DM, Shaul YD, Yung Y, Yarom N, Yao Z, Hanoch T, Seger R. Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function. Mol Cell Biol. 2004 Nov;24(22):10000-15. doi: 10.1128/MCB.24.22.10000-10015.2004. Erratum in: Mol Cell Biol. 2017 Aug 28;37(18): PMID: 15509801; PMCID: PMC525466.
Shaul YD, Seger R. Use of inhibitors in the study of MAPK signaling. Methods Mol Biol. 2004;250:113-26. doi: 10.1385/1-59259-671-1:113. PMID: 14755084.
Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S. Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain. Curr Biol. 2002 Sep 3;12(17):1513-8. doi: 10.1016/s0960-9822(02)01107-7. PMID: 12225667.
Litvak V, Tian D, Shaul YD, Lev S. Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades. J Biol Chem. 2000 Oct 20;275(42):32736-46. doi: 10.1074/jbc.M004200200. PMID: 10915788.
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